Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof

US10155789B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Oklahoma · US

Inventors

• Patrick A. McKee · Oklahoma City, US
• Kenneth W. Jackson · Lawrenceville, US
• Victoria J. Christiansen · Oklahoma City, US

Key dates

• Filing date: May 23, 2017
• Grant date: Dec 18, 2018
• Expiry date: May 23, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.