Red fluorescent aldehyde dehydrogenase (ALDH) substrate

US10156521B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Martin G. Pomper · Baltimore, US
• Haofan Wang · Rockville, US
• Il Minn · Ellicott City, US
• Steven D. Leach · Baltimore, US
• Ronnie C. Mease · Fairfax, US

Key dates

• Filing date: Feb 21, 2014
• Grant date: Dec 18, 2018
• Expiry date: Feb 21, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/6439
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.