Methods for enhancing hematopoietic stem/progenitor cell engraftment
US10159697B2 · kind B2 · utility
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Key dates
| Filing date | Jul 17, 2017 |
| Grant date | Dec 25, 2018 |
| Priority date | — |
| Expiry date | Jul 17, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
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