Quinolone derivatives as antibacterials

US10160726B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Javier de Vicente Fidalgo · Foster City, US
• Haiying He · Shanghai, CN
• Cheng Hu · Menlo Park, US
• Zhigan Jiang · Shanghai, CN
• Xiaolin Li · San Diego, US
• Peichao Lu · Pleasant Hill, US
• Wosenu Mergo · Oakland, US
• Daniel Mutnick · San Diego, US
• Folkert Reck · Walnut Creek, US
• Alexey Rivkin · Emeryville, US
• Colin Keith SKEPPER · Alameda, US
• Xiaojing Wang · Foster City, US
• Jianhua XIA · Shanghai, CN
• Yongjin Xu · Castro Valley, US

Key dates

• Filing date: Aug 3, 2015
• Grant date: Dec 25, 2018
• Expiry date: Aug 3, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.