Compounds and methods for kinase modulation, and indications therefor

US10160747B2 · kind B2 · utility

Assignee

• Plexxikon Inc. · US

Inventors

• Jack Lin · Hercules, US
• Prabha N. Ibrahim · Mountain View, US
• Aaron Edward Albers · San Francisco, US
• John Buell · San Francisco, US
• Zuojun Guo · Pasadena, US
• Phuongly Pham · Hayward, US
• Hannah Powers · Berkeley, US
• Songyuan Shi · Fremont, US
• Wayne Spevak · Berkeley, US
• Guoxian Wu · Palo Alto, US
• Jiazhong Zhang · Foster City, US
• Ying Zhang · Beijing, CN
• Jeffrey Wu · San Francisco, US

Key dates

• Filing date: Mar 15, 2017
• Grant date: Dec 25, 2018
• Expiry date: Mar 15, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R3, R4, R5, each R7, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.