Compounds and methods for kinase modulation, and indications therefor

US10160755B2 · kind B2 · utility

Assignee

• Plexxikon Inc. · US

Inventors

• Jack Lin · Hercules, US
• Phuongly Pham · Hayward, US
• John Buell · San Francisco, US
• Ken Dong · Berkeley, US
• Prabha N. Ibrahim · Mountain View, US
• Wayne Spevak · Berkeley, US
• Garson Tsang · Moraga, US
• Guoxian Wu · Palo Alto, US
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Apr 7, 2016
• Grant date: Dec 25, 2018
• Expiry date: Apr 7, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R1, R2, Q1, Q2, and Q3, are described in this disclosure, compositions thereof, and methods and uses thereof.