Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof

US10160769B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Jolanta Grembecka · Ann Arbor, US
• Tomasz Cierpicki · Ann Arbor, US
• Dmitry Borkin · Ann Arbor, US
• Jay Hess · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• Xiaoqin Li · Ann Arbor, US
• Kevin Lloyd Greenman · Sunnyvale, US
• Mohamed Ali Mohamed Ali Ibrahim · Mountain View, US
• Artem Plekhov · Fremont, US

Key dates

• Filing date: Oct 18, 2016
• Grant date: Dec 25, 2018
• Expiry date: Oct 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 3: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.