Antibodies against Clostridium difficile toxins and methods of using the same

US10160797B2 · kind B2 · utility

Assignee

• SANOFI PASTEUR BIOLOGICS, LLC · US

Inventors

• Stephen Anderson · Buckshaw Village, GB
• Natalie Anosova · Lexington, US
• Nicola Beltraminelli · L'Essart Mador, FR
• Pierre Garrone · Val-de-Reuil, FR
• Harold Kleanthous · Westford, US
• Jianxin Zhang · Acton, US
• Majid Mehtali · Strasbourg, FR

Key dates

• Filing date: Mar 14, 2014
• Grant date: Dec 25, 2018
• Expiry date: Mar 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Monoclonal antibodies or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile ) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile -associated disease. C. difficile is a gram positive, anaerobic bacterium that causes gastrointestinal disease in humans. The bacteria are transmitted through feces and spread to food and other surfaces when people who are infected do not thoroughly wash their hands.