Tissue plasminogen activator antibodies and methods of use
US10160813B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 22, 2014 |
| Grant date | Dec 25, 2018 |
| Priority date | — |
| Expiry date | Dec 5, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96433
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A molecule that binds specifically to a human tissue plasminogen activator (TPA) or a TPA mutant is provided. The molecule having sub-nanomolar affinity to inhibit fibrin-dependent plasminogen activation with an IC50<5 nM, to inhibit degradation of human fibrin clots without affecting TPA amidolytic activity or non-fibrin-dependent activation, and the amino acid sequence of the TPA mutant is at least 65% identical to SEQ ID NO: 1 or SEQ ID NO: 2. Further provided is a method for treating systemic bleeding and brain hemorrhage after TPA treatment in a patient in need of such treatment. The method comprises administering to said patient an effective amount of the molecule, wherein the molecule selectively inhibits fibrin-augmented plasminogen activation in the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.