Patent · US Active

Diagnostic miRNA profiles in multiple sclerosis

US10161004B2 · kind B2 · utility

0Cited by

0References

6Claims

0Family size

Assignee

Siemens Aktiengesellschaft · DE

Inventors

Andreas Keller · Ettlingen, DE
Eckart Meese · Hütschenhausen, DE
Cord Friedrich Stähler · Schriesheim, DE
Andreas Kappel · Höhenkirchen-Siegertsbrunn, DE
Petra Leidinger · Wadern, DE
Christina Backes · Saarburg, DE

Key dates

Filing date	Apr 18, 2013
Grant date	Dec 25, 2018
Priority date	—
Expiry date	Apr 18, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/178
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.