Method and system for determining a corrected value of magnetic resonance relaxometry data of a subject's visceral tissue for extracellular fluid based on a normal iron content for the visceral tissue
US10162031B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2014 |
| Grant date | Dec 25, 2018 |
| Priority date | — |
| Expiry date | Jul 1, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30056
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present disclosure provides systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry. In a non-limiting embodiment, the systems and methods include: obtaining a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device; determining an iron content for the liver; simulating a measurement of the subject's liver for extracellular fluid for the determined iron content; comparing the measurement of the subject's liver for extracellular fluid to the simulated measurement of the subject's liver for extracellular fluid; and determining from said comparison a value of extracellular fluid in the subject's liver based on a normal iron content for the liver. The simulation can include multi-compartment modeling of various fractions of extracellular fluid in the liver and the impact of iron content in the liver on both the intra- and extracellular relaxation times.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.