Bicyclic aryl sphingosine 1-phosphate analogs

US10166250B2 · kind B2 · utility

Assignee

• Biogen MA Inc. · US

Inventors

• Jermaine Thomas · Chelsea, US
• Xiaogao Liu · Dover, US
• Edward Yin-Shiang Lin · Ashland, US
• Guo Zhu Zheng · Lexington, US
• Bin Ma · Arlington, US
• Richard D. Caldwell · Melrose, US
• Kevin M. Guckian · Northborough, US
• Gnanasambandam Kumaravel · Westford, US
• Arthur G. Taveras · Rockaway, US

Key dates

• Filing date: Oct 13, 2017
• Grant date: Jan 1, 2019
• Expiry date: Oct 13, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.