Tripartite cancer theranostic nucleic acid constructs

US10166300B2 · kind B2 · utility

Assignees

• Virginia Commonwealth University · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Paul Fisher · Scarsdale, US
• Swadesh K. Das · Richmond, US
• Mitchell E. Menezes · Richmond, US
• Devanand Sarkar · Richmond, US
• Martin G. Pomper · Baltimore, US

Key dates

• Filing date: Jun 4, 2014
• Grant date: Jan 1, 2019
• Expiry date: Jun 4, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.