Patent · US Active

1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof

US10167299B2 · kind B2 · utility

0Cited by

1References

41Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Hong Liu · Shanghai, CN
Beili Wu · Shanghai, CN
Yongtang Zheng · Kunming, CN
Xin XIE · Shanghai, CN
Hualiang Jiang · Shanghai, CN
Panfeng Peng · Shanghai, CN
Ronghua Luo · Ningbo City, CN
Jing Li · Lansdale, US
Jian Li · Shanghai, CN
Ya-Jun Zhu · Dongguan, CN
Ying Chen · Los Angeles, US
Haonan Zhang · Shanghai, CN
Liumeng Yang · Kunming, CN
Yu Zhou · Shanghai, CN
Kaixian Chen · Shanghai, CN

Key dates

Filing date	Dec 29, 2014
Grant date	Jan 1, 2019
Priority date	—
Expiry date	Dec 29, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D451/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by frmula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.