Patent · US Active

Selective caspase inhibitors and uses thereof

US10167313B2 · kind B2 · utility

1Cited by
10References
22Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 6, 2017
Grant dateJan 1, 2019
Priority date—
Expiry dateJan 6, 2037

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K5/06139
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention relates to compounds of Formula I, IA, II, IIA, III, or IIIA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.