Bioreactor and method of forming complex three-dimensional tissue constructs

US10167444B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Lisa M. Larkin · Ann Arbor, US
• Ellen M. Arruda · Ann Arbor, US
• Michael Smietana · Lake Orion, US
• Pablo Moncada-Larrotiz · Ann Arbor, US

Key dates

• Filing date: Jul 15, 2016
• Grant date: Jan 1, 2019
• Expiry date: Jul 15, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2240/001
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.