Analysis of nucleic acids

US10167509B2 · kind B2 · utility

Assignee

• Bio-Rad Laboratories, Inc. · US

Inventors

• John Frederick Regan · San Mateo, US
• Serge Saxonov · Oakland, US
• Michael Lucero · South San Francisco, US
• Benjamin Hindson · Pleasanton, US
• Phillip Belgrader · Severna Park, US
• Simant Dube · Mountain View, US
• Austin So · Pleasanton, US
• Jeffrey Mellen · San Francisco, US
• Nicholas Heredia · Störitzseestraße, US
• Kevin Ness · Pleasanton, US
• Billy W. Colston, Jr. · San Ramon, US

Key dates

• Filing date: Sep 8, 2015
• Grant date: Jan 1, 2019
• Expiry date: Jan 9, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/172
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.