Methods of identifying modulators of sestrin-gator-2 interaction for modulating mTORC1 activity
US10168338B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Sep 11, 2015 |
| Grant date | Jan 1, 2019 |
| Priority date | — |
| Expiry date | Sep 11, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.