Patent · US Active

Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures

US10172306B2 · kind B2 · utility

0Cited by

0References

12Claims

0Family size

Assignee

Phyton Holdings, LLC · US

Inventors

Gilbert Gorr · Glückstadt, DE
David Alexander Ullisch · Hamburg, DE
Yantree Devi Sankar-Thomas · Tornesch, DE
Thomas Selge · Escheburg, DE
Thomas Leibold · Braunschweig, DE
Harald Heckenmuller · Seevetal, DE

Key dates

Filing date	Mar 18, 2016
Grant date	Jan 8, 2019
Priority date	—
Expiry date	Mar 18, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N5/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.