Nanoparticle

US10172807B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Rosario Lizio · Dieburg, DE
• Silko Grimm · Roßdorf, DE
• Hans-Ulrich Petereit · Darmstadt, DE
• Matthias Epple · Hattingen, DE
• Gregor Doerdelmann · Haan, DE

Key dates

• Filing date: May 26, 2015
• Grant date: Jan 8, 2019
• Expiry date: Jun 12, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.