Cell
US10172885B2 · kind B2 · utility
16Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2014 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Nov 21, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens, and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.