Cell
US10172886B2 · kind B2 · utility
12Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2014 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Aug 15, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens, wherein the spacer of the first CAR is different to the spacer of the second CAR and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.