Mosaic vaccines for serotype a foot-and-mouth disease virus

US10172933B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Aida Elizabeth Rieder · Westbrook, US
• William M. Fischer · Los Alamos, US
• Devendra Rai · Old Saybrook, US

Key dates

• Filing date: Oct 17, 2017
• Grant date: Jan 8, 2019
• Expiry date: Oct 17, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A40/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.