Polymeric nanoparticles

US10172956B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Craig L. Duvall · Nashville, US
• Christopher E. Nelson · Nashville, US
• James R. KINTZING · Concord, US
• Joshua M. Shannon · Nashville, US
• Mukesh K. Gupta · Nashville, US
• Scott A. Guelcher · Spring Hill, US
• Elizabeth J. Adolph · Nashville, US
• Jeffrey M. Davidson · Nashville, US

Key dates

• Filing date: Oct 28, 2013
• Grant date: Jan 8, 2019
• Expiry date: Oct 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y502/01008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.