Compounds, compositions, and methods for increasing CFTR activity
US10174014B2 · kind B2 · utility
8Cited by
11References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 19, 2015 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Jun 19, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure features disclosed compounds which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.