Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic

US10174050B2 · kind B2 · utility

Assignee

• UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 · FR

Inventors

• Nicolas Willand · Lille, FR
• Benoit Deprez · Lille, FR
• Alain Baulard · Templeuve, BE
• Priscille Brodin · Paris, FR
• Matthieu Frederik Desroses · Knivsta, SE
• Laurence Agouridas-Dutot · Lille, FR

Key dates

• Filing date: Dec 20, 2013
• Grant date: Jan 8, 2019
• Expiry date: Feb 22, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns a spiroisoxazoline compound of general formula (I): in which m and n are 0 or 1, R1 represents, inter alia, an optionally substituted alkyl chain, in particular substituted with fluorine or with a cyclic group, and R2 is chosen from phenyl and optionally substituted benzyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the heterocycles having 5 or 6 vertices comprising at least one atom chosen from S, N and O. The present invention also concerns the use of this compound as a drug, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.