Type of cytidine derivative and application thereof
US10174067B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Jun 9, 2015 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Jun 9, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides a new cytidine derivative having the general formula (I), and applications thereof:As demonstrated by experiments on the growth inhibition effect of the new cytidine derivative of the present invention on HCT-116 colon cancer xenografts in tumor-bearing nude mice, the compound of the present invention has high anti-tumor activity, data of impacts on weight of nude mice bearing human colon cancer HCT-116 and data of mortality rate showed that the toxicity of the compound is comparatively low.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.