Methods and compositions for treating solid tumors and enhancing tumor vaccines
US10174120B2 · kind B2 · utility
3Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 20, 2016 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Jan 20, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/726
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.