Modified L-asparaginase

US10174302B1 · kind B1 · utility

Assignees

• XL-PROTEIN GMBH · DE
• Jazz Pharmaceuticals Ireland Limited · IE

Inventors

• Lars Friedrich · Weinheim, DE
• Anne O'Donnell · Dublin, IE

Key dates

• Filing date: Aug 7, 2017
• Grant date: Jan 8, 2019
• Expiry date: Aug 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide consists solely of proline and alanine amino acid residues, and methods of preparation and use thereof.