Recombinant cell producing 2-hydroxyisobutyric acid

US10174349B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Liv Reinecke · Essen, DE
• Steffen Schaffer · Herten, DE
• Achim Marx · Bielefeld, DE
• Markus Poetter · Munster, DE
• Thomas Haas · Munster, DE

Key dates

• Filing date: Apr 28, 2009
• Grant date: Jan 8, 2019
• Expiry date: Jul 15, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/42
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.