Personalized myeloma detection
US10175242B2 · kind B2 · utility
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2References
21Claims
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Assignee
Inventor
Key dates
| Filing date | Feb 28, 2015 |
| Grant date | Jan 8, 2019 |
| Priority date | — |
| Expiry date | Feb 28, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16C20/60
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein is a personalized method for monitoring a condition or disorder associated with antibody production in a subject. The method can involve treating a biological sample comprising immunoglobulin from the subject to enzymatically cleave a target immunoglobulin associated with the PCD into one or more variable domain peptide fragments of the target immunoglobulin, and then measuring the one or more variable domain peptide fragments in the sample by quantitative mass spectrometry to quantify the amount of the target immunoglobulin in the sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.