Treating soft tissue via controlled drug release

US10179111B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Riccardo Gottardi · Pittsburgh, US
• Peter Alexander · Winter Garden, US
• Patrick A. Bianconi · Wexford, US
• Steven R. Little · Washington, US

Key dates

• Filing date: Mar 5, 2015
• Grant date: Jan 15, 2019
• Expiry date: Mar 5, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.