Methods for detecting an analyte and performing a failsafe step in a body fluid using optical and impedance measurements

US10180420B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Klaus Andreas Bauer-Espindola · Mannheim, DE
• Carina Horn · Biblis, DE
• Michael Marquant · Mannheim, DE
• Christine Nortmeyer · Mannheim, DE
• Volker Unkrig · Ladenburg, DE

Key dates

• Filing date: Dec 9, 2015
• Grant date: Jan 15, 2019
• Expiry date: Dec 9, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/7786
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.