Magnetic resonance system and method for detecting the buildup of the transfer of changes in magnetization from nuclei in mobile solute molecules in tissue
US10180478B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 12, 2014 |
| Grant date | Jan 15, 2019 |
| Priority date | — |
| Expiry date | Aug 4, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/465
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An embodiment in accordance with the present invention provides a new MRI method to image the buildup of exchange transfer processes from nuclei in mobile solute molecules in tissue via another molecule (e.g. solvent such as water). The pulse sequence can detect Chemical Exchange Saturation Transfer (CEST), relayed Nuclear Overhauser Enhancement (rNOE) CEST, and selective induced exchange transfer processes. Further, the proposed MRI pulse sequence involves acquiring two or more images with a difference in waiting period (delay) after a radiofrequency excitation, saturation pulse, or series of such pulses. This produces a series of exchange transfer images sensitive to the speed of transfer of changes in magnetization. Subtracting two images or fitting a time series produces maps with minimum interference from direct water saturation and from semi-solid magnetization transfer and other fast exchanging protons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.