Solid phase extraction with capillary electrophoresis

US10181396B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• John Scott Mellors · Carrboro, US
• William A. Black · Durham, US
• John Michael Ramsey · Chapel Hill, US

Key dates

• Filing date: Jun 29, 2017
• Grant date: Jan 15, 2019
• Expiry date: Jun 29, 2037

Classification

• Technology area (CPC H): Electricity
• CPC primary: H01J49/165
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer but optical or other electronic detectors may also be used with the fluidic devices.