Use of single dendritic wedge cell penetrating peptides to facilitate cellular delivery of nanoparticles and nanoparticles carrying cargos

US10183080B2 · kind B2 · utility

Assignee

• The Government of the United States of America, as represented by the Secretary of the Navy · US

Inventors

• Igor L. Medintz · Springfield, US
• James B. Delehanty · Washington, US
• Joyce Breger · Greenbelt, US
• Markus Muttenthaler · Brisbane, AU
• Philip E. Dawson · Solana Beach, US

Key dates

• Filing date: Sep 1, 2017
• Grant date: Jan 22, 2019
• Expiry date: Sep 1, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/6929
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif.