Implantable devices and methods for evaluation of active agents
US10183155B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 18, 2016 |
| Grant date | Jan 22, 2019 |
| Priority date | — |
| Expiry date | Oct 19, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.