Patent · US Active

Tangential flow filtration based protein refolding methods

US10183967B2 · kind B2 · utility

5Cited by
3References
11Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 11, 2014
Grant dateJan 22, 2019
Priority date—
Expiry dateFeb 11, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/30
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.