Stabilized STAT3 decoy oligonucleotides and uses therefor
US10183977B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jun 1, 2017 |
| Grant date | Jan 22, 2019 |
| Priority date | — |
| Expiry date | Jun 1, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.