Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
US10183998B2 · kind B2 · utility
4Cited by
188References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 28, 2016 |
| Grant date | Jan 22, 2019 |
| Priority date | — |
| Expiry date | Nov 28, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.