Methods and materials for treating cancer

US10188713B2 · kind B2 · utility

Assignees

• Mayo Foundation for Medical Education and Research · US
• University of Leeds · GB

Inventors

• Richard G. Vile · Rochester, US
• Timothy J. Kottke · Oronoco, US
• Jill M. Thompson · Stewartville, US
• Jose S. Pulido · Rochester, US
• Alan A. Melcher · Leeds, GB
• Peter Selby · Leeds, GB

Key dates

• Filing date: Mar 19, 2015
• Grant date: Jan 29, 2019
• Expiry date: Apr 28, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20243
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.