Chemical modulators of immune checkpoints and therapeutic use
US10189797B2 · kind B2 · utility
11Cited by
1References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Dec 30, 2016 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Dec 30, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/3955
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.