Bi-benzyl isoquinoline derivative, preparation method and use thereof in hepatopathy treatment and prevention

US10189812B2 · kind B2 · utility

Assignees

• THE KEY LABORATORY OF CHEMISTRY FOR NATURAL PRODUC · CN
• Versitech Limited · CN

Inventors

• Weidong Pan · Somerville, US
• Yibin Feng · Hong Kong, CN
• Yazhou Liu · Xi'an, CN
• Ning Wang · 红钢城街道, CN
• Lan Huang · The Bronx, US
• Guangyi Liang · Guiyang, CN
• Maosheng Zhang · Guiyang, CN
• Tianlei LI · Guiyang, CN
• Huayong Lou · Guiyang, CN
• Zhanxing Hu · Guiyang, CN
• Sheng Liu · San Jose, US
• Peixue Cao · Guiyang, CN
• Jinghua Ruan · Guiyang, CN
• Junjie Lan · Guiyang, CN
• Chao-Lin Chen · Tainan, TW

Key dates

• Filing date: Jun 29, 2015
• Grant date: Jan 29, 2019
• Expiry date: Jun 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.