Purinones as ubiquitin-specific protease 1 inhibitors

US10189841B2 · kind B2 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Alexandre Joseph Buckmelter · Superior, US
• Stephanos Ioannidis · Natick, US
• Bruce Follows · Littleton, US
• Gary Gustafson · Ridgefield, US
• Minghua Wang · Acton, US
• Justin Andrew Caravella · Cambridge, US
• Zhongguo Wang · Lexington, US
• Edward L. Fritzen · Niantic, US
• Jian Lin · Watertown, US

Key dates

• Filing date: Nov 18, 2016
• Grant date: Jan 29, 2019
• Expiry date: Nov 18, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.