DNA gridiron compositions and methods
US10189874B2 · kind B2 · utility
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Key dates
| Filing date | Feb 25, 2015 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Feb 25, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.