Non-hemolytic LLO fusion proteins and methods of utilizing same
US10189885B2 · kind B2 · utility
6Cited by
44References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 1, 2015 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Aug 9, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.