Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants

US10189908B2 · kind B2 · utility

Assignee

• THE UNIVERSITY OF CHICAGO · US

Inventors

• Hans Schreiber · Aichach, DE
• Christian Idel · Chicago, US
• Boris Engels · Arlington, US

Key dates

• Filing date: Feb 5, 2015
• Grant date: Jan 29, 2019
• Expiry date: Apr 8, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon-optimized coding regions and polynucleotides comprising coding regions that are not codon-optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer.