Antidotes for factor Xa inhibitors and methods of using the same
US10190111B2 · kind B2 · utility
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32References
10Claims
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Key dates
| Filing date | Feb 16, 2017 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Feb 16, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.