Method for producing polyunsaturated fatty acids

US10190131B2 · kind B2 · utility

Assignee

• BASF Plant Science Company GmbH · DE

Inventors

• Petra Cirpus · Mannheim, DE
• Jörg Bauer · Weingarten, DE
• Xiao Qiu · Beijing, CN
• Guohai Wu · Saskatoon, CA
• Bifang Cheng · Saskatoon, CA
• Martin Truksa · La Ronge, CA
• Tom Wetjen · Mannheim, DE

Key dates

• Filing date: Feb 21, 2007
• Grant date: Jan 29, 2019
• Expiry date: Nov 26, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y114/19
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.