Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
US10190132B2 · kind B2 · utility
1Cited by
18References
38Claims
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Key dates
| Filing date | Sep 2, 2016 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Sep 2, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06F2209/508
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.